6CKO

Crystal structure of an AF10 fragment

Summary for 6CKO

Entry DOI	10.2210/pdb6cko/pdb
Descriptor	Protein AF-10, Histone-lysine N-methyltransferase, H3 lysine-79 specific, ZINC ION, ... (5 entities in total)
Functional Keywords	structural genomics, structural genomics consortium, sgc, dna binding protein-transferase complex, dna binding protein/transferase
Biological source	Homo sapiens (Human) More
Cellular location	Nucleus : P55197 F1Q4W7
Total number of polymer chains	4
Total formula weight	29854.48
Authors	Zhang, H.,Tempel, W.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Min, J.,Structural Genomics Consortium (SGC) (deposition date: 2018-02-28, release date: 2018-03-21, Last modification date: 2018-04-18)
Primary citation	Zhang, H.,Zhou, B.,Qin, S.,Xu, J.,Harding, R.,Tempel, W.,Nayak, V.,Li, Y.,Loppnau, P.,Dou, Y.,Min, J. Structural and functional analysis of the DOT1L-AF10 complex reveals mechanistic insights into MLL-AF10-associated leukemogenesis. Genes Dev., 32:341-346, 2018 Cited by PubMed: 29563185 DOI: 10.1101/gad.311639.118 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation