6CK2
Insulin analog containing a YB26W mutation
Summary for 6CK2
Entry DOI | 10.2210/pdb6ck2/pdb |
Descriptor | Insulin A chain, Insulin B chain, ZINC ION, ... (6 entities in total) |
Functional Keywords | long-acting, basal, therapeutic, peptide hormone, diabetes, biomolecular engineering, hormone |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 11911.69 |
Authors | Rege, N.K.,Yee, V.C.,Weiss, M.A. (deposition date: 2018-02-27, release date: 2018-06-13, Last modification date: 2023-10-04) |
Primary citation | Rege, N.K.,Wickramasinghe, N.P.,Tustan, A.N.,Phillips, N.F.B.,Yee, V.C.,Ismail-Beigi, F.,Weiss, M.A. Structure-based stabilization of insulin as a therapeutic protein assembly via enhanced aromatic-aromatic interactions. J. Biol. Chem., 293:10895-10910, 2018 Cited by PubMed: 29880646DOI: 10.1074/jbc.RA118.003650 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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