6CJX

Crystal structure of a Fc fragment LALA mutant (L234A, L235A) of human IgG1 (crystal form 2)

Summary for 6CJX

Entry DOI	10.2210/pdb6cjx/pdb
Descriptor	Fc fragment of human IgG1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
Functional Keywords	immunoglobulin, igg1, immune system, immunoglobulin-like beta sandwich, fc fragment, lala mutation
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	51225.28
Authors	Van, V.,Tolbert, W.D.,Pazgier, M. (deposition date: 2018-02-27, release date: 2019-03-06, Last modification date: 2023-10-04)
Primary citation	Orlandi, C.,Deredge, D.,Ray, K.,Gohain, N.,Tolbert, W.,DeVico, A.L.,Wintrode, P.,Pazgier, M.,Lewis, G.K. Antigen-Induced Allosteric Changes in a Human IgG1 Fc Increase Low-Affinity Fc gamma Receptor Binding. Structure, 2020 Cited by PubMed: 32209433 DOI: 10.1016/j.str.2020.03.001 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.44 Å)

Structure validation