6CJX
Crystal structure of a Fc fragment LALA mutant (L234A, L235A) of human IgG1 (crystal form 2)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Fc fragment of human IgG1 | polymer | 214 | 24149.3 | 2 | UniProt (Q6MZV7) Pfam (PF07654) In PDB | Homo sapiens (Human) | |
| 2 | C, D | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1463.3 | 2 | In PDB GlyTouCan (G80858MF) | |||
| 3 | water | water | 18.0 | 3 | Chemie (HOH) |
Sequence modifications
A, B: 234 - 447 (UniProt: Q6MZV7)
| PDB | External Database | Details |
|---|---|---|
| Ala 234 | Leu 260 | engineered mutation |
| Ala 235 | Leu 261 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 48298.6 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 2926.7 | |
| All* | Total formula weight | 51225.3 |
