6CGE
Crystal structure of human 17beta-HSD type 1 in ternary complex with PBRM and NADP+
Summary for 6CGE
Entry DOI | 10.2210/pdb6cge/pdb |
Descriptor | Estradiol 17-beta-dehydrogenase 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-{[(14beta,16alpha,17alpha)-3-(2-bromoethyl)-17-hydroxyestra-1,3,5(10)-trien-16-yl]methyl}benzamide, ... (4 entities in total) |
Functional Keywords | inhibitor, complex, hydroxysteroid dehydrogenase, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 72457.77 |
Authors | |
Primary citation | Li, T.,Maltais, R.,Poirier, D.,Lin, S.X. Combined Biophysical Chemistry Reveals a New Covalent Inhibitor with a Low-Reactivity Alkyl Halide. J Phys Chem Lett, 9:5275-5280, 2018 Cited by PubMed: 30148957DOI: 10.1021/acs.jpclett.8b02225 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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