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6CGE

Crystal structure of human 17beta-HSD type 1 in ternary complex with PBRM and NADP+

Functional Information from GO Data
ChainGOidnamespacecontents
A0003824molecular_functioncatalytic activity
A0004303molecular_functionestradiol 17-beta-dehydrogenase [NAD(P)] activity
A0005496molecular_functionsteroid binding
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006629biological_processlipid metabolic process
A0006694biological_processsteroid biosynthetic process
A0006703biological_processestrogen biosynthetic process
A0007040biological_processlysosome organization
A0007519biological_processskeletal muscle tissue development
A0008210biological_processestrogen metabolic process
A0010467biological_processgene expression
A0016491molecular_functionoxidoreductase activity
A0030283molecular_functiontestosterone dehydrogenase [NAD(P)] activity
A0035410molecular_functiondihydrotestosterone 17-beta-dehydrogenase activity
A0036094molecular_functionsmall molecule binding
A0042803molecular_functionprotein homodimerization activity
A0047035molecular_functiontestosterone dehydrogenase (NAD+) activity
A0047045molecular_functiontestosterone 17-beta-dehydrogenase (NADP+) activity
A0050661molecular_functionNADP binding
A0060348biological_processbone development
A0060612biological_processadipose tissue development
A0061370biological_processtestosterone biosynthetic process
A0070401molecular_functionNADP+ binding
A0071248biological_processcellular response to metal ion
A0072582molecular_function17-beta-hydroxysteroid dehydrogenase (NADP+) activity
A1903924molecular_functionestradiol binding
B0003824molecular_functioncatalytic activity
B0004303molecular_functionestradiol 17-beta-dehydrogenase [NAD(P)] activity
B0005496molecular_functionsteroid binding
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006629biological_processlipid metabolic process
B0006694biological_processsteroid biosynthetic process
B0006703biological_processestrogen biosynthetic process
B0007040biological_processlysosome organization
B0007519biological_processskeletal muscle tissue development
B0008210biological_processestrogen metabolic process
B0010467biological_processgene expression
B0016491molecular_functionoxidoreductase activity
B0030283molecular_functiontestosterone dehydrogenase [NAD(P)] activity
B0035410molecular_functiondihydrotestosterone 17-beta-dehydrogenase activity
B0036094molecular_functionsmall molecule binding
B0042803molecular_functionprotein homodimerization activity
B0047035molecular_functiontestosterone dehydrogenase (NAD+) activity
B0047045molecular_functiontestosterone 17-beta-dehydrogenase (NADP+) activity
B0050661molecular_functionNADP binding
B0060348biological_processbone development
B0060612biological_processadipose tissue development
B0061370biological_processtestosterone biosynthetic process
B0070401molecular_functionNADP+ binding
B0071248biological_processcellular response to metal ion
B0072582molecular_function17-beta-hydroxysteroid dehydrogenase (NADP+) activity
B1903924molecular_functionestradiol binding
Functional Information from PDB Data
site_idAC1
Number of Residues16
Detailsbinding site for residue NAP A 401
ChainResidue
AGLY9
AASN90
AALA91
AGLY92
ATHR190
AHOH501
AHOH505
AHOH512
ASER11
ASER12
AGLY13
AILE14
AARG37
ALEU64
AASP65
AVAL66

site_idAC2
Number of Residues16
Detailsbinding site for residue F0D A 402
ChainResidue
AGLY94
ALEU95
ASER142
AGLY144
ALEU149
AASN152
ATYR155
ACYS185
AGLY186
APRO187
ALEU197
ATYR218
AHIS221
ASER222
APHE259
AGLU282

site_idAC3
Number of Residues17
Detailsbinding site for residue NAP B 401
ChainResidue
BGLY9
BSER11
BSER12
BGLY13
BILE14
BARG37
BLEU64
BASP65
BVAL66
BARG67
BALA91
BGLY92
BTHR190
BHOH505
BHOH509
BHOH512
BHOH515

site_idAC4
Number of Residues20
Detailsbinding site for Di-peptide F0D B 402 and HIS B 221
ChainResidue
BGLY94
BLEU95
BSER142
BVAL143
BLEU149
BASN152
BTYR155
BCYS185
BGLY186
BPRO187
BGLN217
BTYR218
BLEU219
BALA220
BSER222
BLYS223
BGLN224
BVAL225
BGLU282
BVAL283

Functional Information from PROSITE/UniProt
site_idPS00061
Number of Residues29
DetailsADH_SHORT Short-chain dehydrogenases/reductases family signature. SvgglmglpfNdvYCASKFALeGLCeSLA
ChainResidueDetails
ASER142-ALA170

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor
ChainResidueDetails
ATYR155
BTYR155

site_idSWS_FT_FI2
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:8805577
ChainResidueDetails
AGLY9
AASP65
ASER142
ALYS159
BGLY9
BASP65
BSER142
BLYS159

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:8994190
ChainResidueDetails
ASER134
BSER134

218853

PDB entries from 2024-04-24

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