6CGE
Crystal structure of human 17beta-HSD type 1 in ternary complex with PBRM and NADP+
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004303 | molecular_function | estradiol 17-beta-dehydrogenase [NAD(P)+] activity |
| A | 0005496 | molecular_function | steroid binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006694 | biological_process | steroid biosynthetic process |
| A | 0006703 | biological_process | estrogen biosynthetic process |
| A | 0036094 | molecular_function | small molecule binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0047035 | molecular_function | testosterone dehydrogenase (NAD+) activity |
| A | 0047045 | molecular_function | testosterone dehydrogenase (NADP+) activity |
| A | 0050661 | molecular_function | NADP binding |
| A | 0060348 | biological_process | bone development |
| A | 0061370 | biological_process | testosterone biosynthetic process |
| A | 0070401 | molecular_function | NADP+ binding |
| A | 0071248 | biological_process | cellular response to metal ion |
| A | 0072582 | molecular_function | 17-beta-hydroxysteroid dehydrogenase (NADP+) activity |
| A | 1903924 | molecular_function | estradiol binding |
| B | 0004303 | molecular_function | estradiol 17-beta-dehydrogenase [NAD(P)+] activity |
| B | 0005496 | molecular_function | steroid binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006694 | biological_process | steroid biosynthetic process |
| B | 0006703 | biological_process | estrogen biosynthetic process |
| B | 0036094 | molecular_function | small molecule binding |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0047035 | molecular_function | testosterone dehydrogenase (NAD+) activity |
| B | 0047045 | molecular_function | testosterone dehydrogenase (NADP+) activity |
| B | 0050661 | molecular_function | NADP binding |
| B | 0060348 | biological_process | bone development |
| B | 0061370 | biological_process | testosterone biosynthetic process |
| B | 0070401 | molecular_function | NADP+ binding |
| B | 0071248 | biological_process | cellular response to metal ion |
| B | 0072582 | molecular_function | 17-beta-hydroxysteroid dehydrogenase (NADP+) activity |
| B | 1903924 | molecular_function | estradiol binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | binding site for residue NAP A 401 |
| Chain | Residue |
| A | GLY9 |
| A | ASN90 |
| A | ALA91 |
| A | GLY92 |
| A | THR190 |
| A | HOH501 |
| A | HOH505 |
| A | HOH512 |
| A | SER11 |
| A | SER12 |
| A | GLY13 |
| A | ILE14 |
| A | ARG37 |
| A | LEU64 |
| A | ASP65 |
| A | VAL66 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | binding site for residue F0D A 402 |
| Chain | Residue |
| A | GLY94 |
| A | LEU95 |
| A | SER142 |
| A | GLY144 |
| A | LEU149 |
| A | ASN152 |
| A | TYR155 |
| A | CYS185 |
| A | GLY186 |
| A | PRO187 |
| A | LEU197 |
| A | TYR218 |
| A | HIS221 |
| A | SER222 |
| A | PHE259 |
| A | GLU282 |
| site_id | AC3 |
| Number of Residues | 17 |
| Details | binding site for residue NAP B 401 |
| Chain | Residue |
| B | GLY9 |
| B | SER11 |
| B | SER12 |
| B | GLY13 |
| B | ILE14 |
| B | ARG37 |
| B | LEU64 |
| B | ASP65 |
| B | VAL66 |
| B | ARG67 |
| B | ALA91 |
| B | GLY92 |
| B | THR190 |
| B | HOH505 |
| B | HOH509 |
| B | HOH512 |
| B | HOH515 |
| site_id | AC4 |
| Number of Residues | 20 |
| Details | binding site for Di-peptide F0D B 402 and HIS B 221 |
| Chain | Residue |
| B | GLY94 |
| B | LEU95 |
| B | SER142 |
| B | VAL143 |
| B | LEU149 |
| B | ASN152 |
| B | TYR155 |
| B | CYS185 |
| B | GLY186 |
| B | PRO187 |
| B | GLN217 |
| B | TYR218 |
| B | LEU219 |
| B | ALA220 |
| B | SER222 |
| B | LYS223 |
| B | GLN224 |
| B | VAL225 |
| B | GLU282 |
| B | VAL283 |
Functional Information from PROSITE/UniProt
| site_id | PS00061 |
| Number of Residues | 29 |
| Details | ADH_SHORT Short-chain dehydrogenases/reductases family signature. SvgglmglpfNdvYCASKFALeGLCeSLA |
| Chain | Residue | Details |
| A | SER142-ALA170 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 62 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"8805577","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by PKA","evidences":[{"source":"PubMed","id":"8994190","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
