6CGE

Crystal structure of human 17beta-HSD type 1 in ternary complex with PBRM and NADP+

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004303	molecular_function	estradiol 17-beta-dehydrogenase [NAD(P)+] activity
A	0005496	molecular_function	steroid binding
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006629	biological_process	lipid metabolic process
A	0006694	biological_process	steroid biosynthetic process
A	0006703	biological_process	estrogen biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0036094	molecular_function	small molecule binding
A	0042803	molecular_function	protein homodimerization activity
A	0047035	molecular_function	testosterone dehydrogenase (NAD+) activity
A	0047045	molecular_function	testosterone dehydrogenase (NADP+) activity
A	0050661	molecular_function	NADP binding
A	0060348	biological_process	bone development
A	0061370	biological_process	testosterone biosynthetic process
A	0070401	molecular_function	NADP+ binding
A	0071248	biological_process	cellular response to metal ion
A	0072582	molecular_function	17-beta-hydroxysteroid dehydrogenase (NADP+) activity
A	1903924	molecular_function	estradiol binding
B	0004303	molecular_function	estradiol 17-beta-dehydrogenase [NAD(P)+] activity
B	0005496	molecular_function	steroid binding
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006629	biological_process	lipid metabolic process
B	0006694	biological_process	steroid biosynthetic process
B	0006703	biological_process	estrogen biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0036094	molecular_function	small molecule binding
B	0042803	molecular_function	protein homodimerization activity
B	0047035	molecular_function	testosterone dehydrogenase (NAD+) activity
B	0047045	molecular_function	testosterone dehydrogenase (NADP+) activity
B	0050661	molecular_function	NADP binding
B	0060348	biological_process	bone development
B	0061370	biological_process	testosterone biosynthetic process
B	0070401	molecular_function	NADP+ binding
B	0071248	biological_process	cellular response to metal ion
B	0072582	molecular_function	17-beta-hydroxysteroid dehydrogenase (NADP+) activity
B	1903924	molecular_function	estradiol binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue NAP A 401

Chain	Residue
A	GLY9
A	ASN90
A	ALA91
A	GLY92
A	THR190
A	HOH501
A	HOH505
A	HOH512
A	SER11
A	SER12
A	GLY13
A	ILE14
A	ARG37
A	LEU64
A	ASP65
A	VAL66

---

site_id	AC2
Number of Residues	16
Details	binding site for residue F0D A 402

Chain	Residue
A	GLY94
A	LEU95
A	SER142
A	GLY144
A	LEU149
A	ASN152
A	TYR155
A	CYS185
A	GLY186
A	PRO187
A	LEU197
A	TYR218
A	HIS221
A	SER222
A	PHE259
A	GLU282

---

site_id	AC3
Number of Residues	17
Details	binding site for residue NAP B 401

Chain	Residue
B	GLY9
B	SER11
B	SER12
B	GLY13
B	ILE14
B	ARG37
B	LEU64
B	ASP65
B	VAL66
B	ARG67
B	ALA91
B	GLY92
B	THR190
B	HOH505
B	HOH509
B	HOH512
B	HOH515

---

site_id	AC4
Number of Residues	20
Details	binding site for Di-peptide F0D B 402 and HIS B 221

Chain	Residue
B	GLY94
B	LEU95
B	SER142
B	VAL143
B	LEU149
B	ASN152
B	TYR155
B	CYS185
B	GLY186
B	PRO187
B	GLN217
B	TYR218
B	LEU219
B	ALA220
B	SER222
B	LYS223
B	GLN224
B	VAL225
B	GLU282
B	VAL283

---

Functional Information from PROSITE/UniProt

site_id	PS00061
Number of Residues	29
Details	ADH_SHORT Short-chain dehydrogenases/reductases family signature. SvgglmglpfNdvYCASKFALeGLCeSLA

Chain	Residue	Details
A	SER142-ALA170

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton acceptor"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	62
Details	Binding site: {"evidences":[{"source":"PubMed","id":"8805577","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by PKA","evidences":[{"source":"PubMed","id":"8994190","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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