6CGD

Aminoglycoside Phosphotransferase (2'')-Ia in complex with GMPPNP, Magnesium, and Amikacin

Summary for 6CGD

Entry DOI	10.2210/pdb6cgd/pdb
Related	6C5U 6CAV 6CEY
Descriptor	Bifunctional AAC/APH, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, (2S)-N-[(1R,2S,3S,4R,5S)-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-5-azanyl-2-[(2S,3R,4S,5S ,6R)-4-azanyl-6-(hydroxymethyl)-3,5-bis(oxidanyl)oxan-2-yl]oxy-3-oxidanyl-cyclohexyl]-4-azanyl-2-oxidanyl-butanamide, ... (6 entities in total)
Functional Keywords	kinase, antibiotic, aminoglycoside, resistance, transferase, transferase-antibiotic complex
Biological source	Staphylococcus aureus
Total number of polymer chains	4
Total formula weight	147353.59
Authors	Caldwell, S.J.,Berghuis, A.M. (deposition date: 2018-02-20, release date: 2018-04-11, Last modification date: 2023-10-04)
Primary citation	Caldwell, S.J.,Berghuis, A.M. Plasticity of Aminoglycoside Binding to Antibiotic Kinase APH(2′′)-Ia. Antimicrob. Agents Chemother., 62:-, 2018 Cited by PubMed: 29661878 DOI: 10.1128/AAC.00202-18 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation