6CDU
Crystal structure of a chimeric human alpha1GABAA receptor in complex with alphaxalone
Summary for 6CDU
Entry DOI | 10.2210/pdb6cdu/pdb |
Descriptor | chimeric alpha1GABAA receptor, (3a,5a)-3-Hydroxypregnane-11,20-dione (2 entities in total) |
Functional Keywords | gabaa receptor, anesthetics, alphaxalone, neurosteroids, protein transport |
Biological source | Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937)) More |
Total number of polymer chains | 10 |
Total formula weight | 375578.36 |
Authors | Chen, Q.,Arjunan, P.,Cohen, A.E.,Xu, Y.,Tang, P. (deposition date: 2018-02-09, release date: 2018-08-22, Last modification date: 2023-10-04) |
Primary citation | Chen, Q.,Wells, M.M.,Arjunan, P.,Tillman, T.S.,Cohen, A.E.,Xu, Y.,Tang, P. Structural basis of neurosteroid anesthetic action on GABAAreceptors. Nat Commun, 9:3972-3972, 2018 Cited by PubMed: 30266951DOI: 10.1038/s41467-018-06361-4 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.45 Å) |
Structure validation
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