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6CDS

Human neurofibromin 2/merlin/schwannomin residues 1-339 in complex with PIP2

Summary for 6CDS
Entry DOI10.2210/pdb6cds/pdb
DescriptorMerlin, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, PHOSPHATE ION, ... (6 entities in total)
Functional Keywordsneurofibromin 2, schwannomin, merlin, tumor suppressor protein, signaling protein
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight82346.45
Authors
Chinthalapudi, K.,Sharff, A.J.,Bricogne, G.,Izard, T. (deposition date: 2018-02-09, release date: 2018-07-18, Last modification date: 2023-10-04)
Primary citationChinthalapudi, K.,Mandati, V.,Zheng, J.,Sharff, A.J.,Bricogne, G.,Griffin, P.R.,Kissil, J.,Izard, T.
Lipid binding promotes the open conformation and tumor-suppressive activity of neurofibromin 2.
Nat Commun, 9:1338-1338, 2018
Cited by
PubMed: 29626191
DOI: 10.1038/s41467-018-03648-4
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.62 Å)
Structure validation

217705

數據於2024-03-27公開中

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