6CCX

NMR data-driven model of GTPase KRas-GMPPNP:Cmpd2 complex tethered to a nanodisc

Summary for 6CCX

• Entry DOI: 10.2210/pdb6ccx/pdb
• NMR Information: BMRB: 30403
• Descriptor: Apolipoprotein A-I, GTPase KRas, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... (7 entities in total)
• Functional Keywords: protein-bilayer-compound complex, membrane protein-oncoprotein complex, membrane protein/oncoprotein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 131749.63

Authors

Fang, Z.,Marshall, C.B.,Nishikawa, T.,Gossert, A.D.,Jansen, J.M.,Jahnke, W.,Ikura, M. (deposition date: 2018-02-07, release date: 2018-09-05, Last modification date: 2023-06-14)

• Primary citation: Fang, Z.,Marshall, C.B.,Nishikawa, T.,Gossert, A.D.,Jansen, J.M.,Jahnke, W.,Ikura, M.; Inhibition of K-RAS4B by a Unique Mechanism of Action: Stabilizing Membrane-Dependent Occlusion of the Effector-Binding Site.; Cell Chem Biol, 25:1327-1336.e4, 2018; PubMed: 30122370; DOI: 10.1016/j.chembiol.2018.07.009

Experimental method

SOLUTION NMR