6C9C

Crystal structure of LpxC from Pseudomonas aeruginosa in complex with racemic ligand PT803

6C9C の概要

• エントリーDOI: 10.2210/pdb6c9c/pdb
• 関連するPDBエントリー: 5UPG 5VWM
• 分子名称: UDP-3-O-acyl-N-acetylglucosamine deacetylase, (2R)-4-[4-{4-[(5-chloro-6-methoxypyridin-3-yl)methoxy]phenyl}-2-oxo-3,6-dihydropyridin-1(2H)-yl]-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide, (2S)-4-[4-{4-[(5-chloro-6-methoxypyridin-3-yl)methoxy]phenyl}-2-oxo-3,6-dihydropyridin-1(2H)-yl]-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide, ... (6 entities in total)
• 機能のキーワード: inhibitor, structural genomics, seattle structural genomics center for infectious disease, ssgcid, lpxc, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Pseudomonas aeruginosa (strain UCBPP-PA14)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35013.90

構造登録者

Seattle Structural Genomics Center for Infectious Disease (SSGCID) (登録日: 2018-01-26, 公開日: 2019-03-13, 最終更新日: 2023-10-04)

• 主引用文献: Delker, S.L.,Mayclin, S.J.,Phan, J.N.,Abendroth, J.,Lorimer, D.,Edwards, T.E.; Crystal structure of LpxC from Pseudomonas aeruginosa in complex with ligand PT803; to be published,

実験手法

X-RAY DIFFRACTION (2 Å)