6C9C
Crystal structure of LpxC from Pseudomonas aeruginosa in complex with racemic ligand PT803
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | UDP-3-O-acyl-N-acetylglucosamine deacetylase | polymer | 304 | 33562.1 | 1 | UniProt (Q02H34) Pfam (PF03331) | Pseudomonas aeruginosa (strain UCBPP-PA14) | UDP-3-O-acyl-GlcNAc deacetylase,UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase |
| 2 | B (A) | (2R)-4-[4-{4-[(5-chloro-6-methoxypyridin-3-yl)methoxy]phenyl}-2-oxo-3,6-dihydropyridin-1(2H)-yl]-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide | non-polymer | 538.0 | 1 | Chemie (EU1) | |||
| 3 | C (A) | (2S)-4-[4-{4-[(5-chloro-6-methoxypyridin-3-yl)methoxy]phenyl}-2-oxo-3,6-dihydropyridin-1(2H)-yl]-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide | non-polymer | 538.0 | 1 | Chemie (F64) | |||
| 4 | D (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 5 | E, F, G, H, I (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 6 | J (A) | water | water | 18.0 | 171 | Chemie (HOH) |
Sequence modifications
A: 1 - 303 (UniProt: Q02H34)
| PDB | External Database | Details |
|---|---|---|
| Ser 0 | - | expression tag |
| Val 33 | Met 33 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33562.1 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1451.8 | |
| All* | Total formula weight | 35013.9 |
