6C89
NDM-1 Beta-Lactamase Exhibits Differential Active Site Sequence Requirements for the Hydrolysis of Penicillin versus Carbapenem Antibiotics
Summary for 6C89
Entry DOI | 10.2210/pdb6c89/pdb |
Descriptor | Beta-lactamase, ZINC ION, 1,2-ETHANEDIOL, ... (7 entities in total) |
Functional Keywords | ndm-1; beta-lactamase; deep sequencing; antibiotic resistance; beta-lactams, antimicrobial protein |
Biological source | Escherichia coli |
Total number of polymer chains | 4 |
Total formula weight | 98758.36 |
Authors | Palzkill, T.,Sun, Z.,Sankaran, B. (deposition date: 2018-01-24, release date: 2018-12-12, Last modification date: 2023-10-04) |
Primary citation | Sun, Z.,Hu, L.,Sankaran, B.,Prasad, B.V.V.,Palzkill, T. Differential active site requirements for NDM-1 beta-lactamase hydrolysis of carbapenem versus penicillin and cephalosporin antibiotics. Nat Commun, 9:4524-4524, 2018 Cited by PubMed: 30375382DOI: 10.1038/s41467-018-06839-1 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75006148726 Å) |
Structure validation
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