6C89
NDM-1 Beta-Lactamase Exhibits Differential Active Site Sequence Requirements for the Hydrolysis of Penicillin versus Carbapenem Antibiotics
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Beta-lactamase | polymer | 231 | 24475.5 | 4 | UniProt (E5KIY2) Pfam (PF00753) In PDB | Escherichia coli | Beta-lactamase NDM-1,BlaNDM-1,BlaNDM-1 metallo beta lactamase,Class B beta-lactamase NDM-1,Metallo-beta-lactamase,Metallo-beta-lactamase NDM-1,NDM-1 metallo-beta-lactamase,New Delhi metallo-beta-lactamase NDM-1,Subclass B1 metallo-beta-lactamase NDM-1 |
| 2 | A, B, C, D | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) | |||
| 3 | A, D | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 4 | A, B | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 5 | B, D | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 6 | C | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 7 | water | water | 18.0 | 675 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 34 - 312 (UniProt: E5KIY2)
| PDB | External Database | Details |
|---|---|---|
| Arg 224 | Lys 211 | engineered mutation |
| Ala 232 | Gly 219 | engineered mutation |
| Gln 233 | Asn 220 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 97902.0 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 856.4 | |
| All* | Total formula weight | 98758.4 |
