6C7S

Structure of Rifampicin Monooxygenase with Product Bound

Summary for 6C7S

• Entry DOI: 10.2210/pdb6c7s/pdb
• Related: 5KOW 5KOX
• Descriptor: Putative rifampin monooxygenase, FLAVIN-ADENINE DINUCLEOTIDE, (1E,3S,4R,5S,6R,7R,8R,9S,10S,11E,13E)-15-amino-1-{[(2S)-5,7-dihydroxy-2,4-dimethyl-8-{(E)-[(4-methylpiperazin-1-yl)imino]methyl}-1,6,9-trioxo-1,2,6,9-tetrahydronaphtho[2,1-b]furan-2-yl]oxy}-7,9-dihydroxy-3-methoxy-4,6,8,10,14-pentamethyl-15-oxopentadeca-1,11,13-trien-5-yl acetate, ... (6 entities in total)
• Functional Keywords: rifampicin, oxidoreductase
• Biological source: Nocardia farcinica (strain IFM 10152)
• Total number of polymer chains: 1
• Total formula weight: 53692.33

Authors

Liu, L.-K.,Tanner, J.J. (deposition date: 2018-01-23, release date: 2018-04-18, Last modification date: 2023-10-04)

• Primary citation: Liu, L.K.,Dai, Y.,Abdelwahab, H.,Sobrado, P.,Tanner, J.J.; Structural Evidence for Rifampicin Monooxygenase Inactivating Rifampicin by Cleaving Its Ansa-Bridge.; Biochemistry, 57:2065-2068, 2018; PubMed: 29578336; DOI: 10.1021/acs.biochem.8b00190

Experimental method

X-RAY DIFFRACTION (2.1 Å)