6C6N
Human squalene epoxidase (SQLE, squalene monooxygenase) structure with FAD and Cmpd-4"
Summary for 6C6N
Entry DOI | 10.2210/pdb6c6n/pdb |
Related | 6C6P 6C6R |
Descriptor | Squalene monooxygenase, GLYCEROL, SULFATE ION, ... (7 entities in total) |
Functional Keywords | cholesterol synthesis pathway, sqle, erg1, fad-dependent monooxygenase, squalene hydroxylase, squalene-2, 3-epoxidase, flavoprotein, oxidoreductase-oxidoreductase inhibitor complex, flavoprotein-inhibitor complex, flavoprotein/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 109122.65 |
Authors | Padyana, A.K.,Jin, L. (deposition date: 2018-01-19, release date: 2019-01-16, Last modification date: 2024-03-13) |
Primary citation | Padyana, A.K.,Gross, S.,Jin, L.,Cianchetta, G.,Narayanaswamy, R.,Wang, F.,Wang, R.,Fang, C.,Lv, X.,Biller, S.A.,Dang, L.,Mahoney, C.E.,Nagaraja, N.,Pirman, D.,Sui, Z.,Popovici-Muller, J.,Smolen, G.A. Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase. Nat Commun, 10:97-97, 2019 Cited by PubMed: 30626872DOI: 10.1038/s41467-018-07928-x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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