6C67

Mycobacterium tuberculosis adenosine kinase bound to iodotubercidin

6C67 の概要

• エントリーDOI: 10.2210/pdb6c67/pdb
• 関連するPDBエントリー: 2PKF 2PKK 2PKM 2PKN
• 分子名称: Adenosine kinase, (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, SODIUM ION, ... (6 entities in total)
• 機能のキーワード: nucleoside analog, complex, inhibitor, structural genomics, psi-2, protein structure initiative, tb structural genomics consortium, tbsgc, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 70906.71

構造登録者

Crespo, R.A.,TB Structural Genomics Consortium (TBSGC) (登録日: 2018-01-17, 公開日: 2019-05-01, 最終更新日: 2023-10-04)

• 主引用文献: Crespo, R.A.,Dang, Q.,Zhou, N.E.,Guthrie, L.M.,Snavely, T.C.,Dong, W.,Loesch, K.A.,Suzuki, T.,You, L.,Wang, W.,O'Malley, T.,Parish, T.,Olsen, D.B.,Sacchettini, J.C.; Structure-Guided Drug Design of 6-Substituted Adenosine Analogues as Potent Inhibitors of Mycobacterium tuberculosis Adenosine Kinase.; J.Med.Chem., 62:4483-4499, 2019; PubMed: 31002508; DOI: 10.1021/acs.jmedchem.9b00020

実験手法

X-RAY DIFFRACTION (2.11 Å)