6C5Q

PPARg LBD bound to SR10171

Summary for 6C5Q

Entry DOI	10.2210/pdb6c5q/pdb
Descriptor	Peroxisome proliferator-activated receptor gamma, 2-{3-[(5-{[(1S)-1-(4-tert-butylphenyl)ethyl]carbamoyl}-2,3-dimethyl-1H-indol-1-yl)methyl]phenoxy}-2-methylpropanoic acid (3 entities in total)
Functional Keywords	peroxisome proliferator activated receptor gamma, pparg, nuclear receptor, inverse agonist, transcription
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	33336.75
Authors	Bruning, J.B.,Frkic, R.L. (deposition date: 2018-01-16, release date: 2018-08-01, Last modification date: 2023-11-15)
Primary citation	Frkic, R.L.,Marshall, A.C.,Blayo, A.L.,Pukala, T.L.,Kamenecka, T.M.,Griffin, P.R.,Bruning, J.B. PPAR gamma in Complex with an Antagonist and Inverse Agonist: a Tumble and Trap Mechanism of the Activation Helix. iScience, 5:69-79, 2018 Cited by PubMed: 30123887 DOI: 10.1016/j.isci.2018.06.012 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.404 Å)

Structure validation