6C5N

Crystal structure of Staphylococcus aureus ketol-acid reductoisomerase with hydroxyoxamate inhibitor 1

Summary for 6C5N

• Entry DOI: 10.2210/pdb6c5n/pdb
• Descriptor: Ketol-acid reductoisomerase (NADP(+)), NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, MAGNESIUM ION, ... (7 entities in total)
• Functional Keywords: ketol-acid reductoisomerase, isomerase, inhibitor, oxidoreductase
• Biological source: Staphylococcus aureus (strain bovine RF122 / ET3-1)
• Total number of polymer chains: 2
• Total formula weight: 77828.71

Authors

Kandale, A.,Patel, K.M.,Zheng, S.,You, L.,Guddat, L.W.,Schenk, G.,Schembri, M.A.,McGeary, R.P. (deposition date: 2018-01-16, release date: 2019-01-30, Last modification date: 2023-10-04)

• Primary citation: Kandale, A.,Patel, K.M.,Zheng, S.,You, L.,Guddat, L.W.,Schenk, G.,Schembri, M.A.,McGeary, R.P.; Design, synthesis, in vitro activity and crystallisation of novel N-isopropyl-N-hydroxyoxamate derivatives as ketol-acid reductosiomerase (KARI) inhibitor; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.673 Å)