6C5N
Crystal structure of Staphylococcus aureus ketol-acid reductoisomerase with hydroxyoxamate inhibitor 1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Ketol-acid reductoisomerase (NADP(+)) | polymer | 339 | 37755.4 | 2 | UniProt (Q2YUF3) Pfam (PF07991) Pfam (PF01450) | Staphylococcus aureus (strain bovine RF122 / ET3-1) | KARI,Acetohydroxy-acid isomeroreductase,AHIR,Alpha-keto-beta-hydroxylacyl reductoisomerase,Ketol-acid reductoisomerase type 1,Ketol-acid reductoisomerase type I |
| 2 | C, J (A, B) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 2 | Chemie (NDP) | |||
| 3 | D, E, K, L (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 4 | F, H (A, B) | [cyclopentyl(hydroxy)amino](oxo)acetic acid | non-polymer | 173.2 | 2 | Chemie (EN4) | |||
| 5 | G, I (A, B) | (cyclopentylamino)(oxo)acetic acid | non-polymer | 157.2 | 2 | Chemie (81B) | |||
| 6 | M (B) | IMIDAZOLE | non-polymer | 69.1 | 1 | Chemie (IMD) | |||
| 7 | N, O (A, B) | water | water | 18.0 | 836 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 334 (UniProt: Q2YUF3)
| PDB | External Database | Details |
|---|---|---|
| His 335 | - | expression tag |
| His 336 | - | expression tag |
| His 337 | - | expression tag |
| His 338 | - | expression tag |
| His 339 | - | expression tag |
| His 340 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 75510.9 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 2317.8 | |
| All* | Total formula weight | 77828.7 |
