6C4A

Crystal structure of 3-nitropropionate modified isocitrate lyase from Mycobacterium tuberculosis with pyruvate

Summary for 6C4A

• Entry DOI: 10.2210/pdb6c4a/pdb
• Descriptor: Isocitrate lyase 1, PYRUVIC ACID, MAGNESIUM ION, ... (7 entities in total)
• Functional Keywords: lyase
• Biological source: Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman)
• Total number of polymer chains: 8
• Total formula weight: 394227.69

Authors

Kreitler, D.F.,Ray, S.,Murkin, A.S.,Gulick, A.M. (deposition date: 2018-01-11, release date: 2018-06-06, Last modification date: 2023-11-15)

• Primary citation: Ray, S.,Kreitler, D.F.,Gulick, A.M.,Murkin, A.S.; The Nitro Group as a Masked Electrophile in Covalent Enzyme Inhibition.; ACS Chem. Biol., 13:1470-1473, 2018; PubMed: 29782144; DOI: 10.1021/acschembio.8b00225

Experimental method

X-RAY DIFFRACTION (1.8 Å)