6C4A
Crystal structure of 3-nitropropionate modified isocitrate lyase from Mycobacterium tuberculosis with pyruvate
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D, E... | Isocitrate lyase 1 | polymer | 442 | 48944.4 | 8 | UniProt (H8EVV4) Pfam (PF00463) UniProt (by SIFTS) (P9WKK7) In PDB | Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman) | ICL1,Isocitrase,Isocitratase,Methylisocitrate lyase,MICA |
2 | E, F, A, G, B... | PYRUVIC ACID | non-polymer | 88.1 | 8 | Chemie (PYR) | |||
3 | E, F, A, B, G... | MAGNESIUM ION | non-polymer | 24.3 | 21 | Chemie (MG) | |||
4 | B, C | 3-NITROPROPANOIC ACID | non-polymer | 119.1 | 2 | Chemie (3NP) | |||
5 | E, F, G, B, C... | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 7 | Chemie (PEG) | |||
6 | F, G | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 2 | Chemie (EPE) | |||
7 | water | water | 18.0 | 2721 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H: 1 - 428 (UniProt: H8EVV4)
PDB | External Database | Details |
---|---|---|
Met -13 | - | initiating methionine |
His -12 | - | expression tag |
His -11 | - | expression tag |
His -10 | - | expression tag |
His -9 | - | expression tag |
His -8 | - | expression tag |
His -7 | - | expression tag |
Leu -6 | - | expression tag |
Val -5 | - | expression tag |
Pro -4 | - | expression tag |
Arg -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 391555.2 | |
Non-Polymers* | Number of molecules | 40 |
Total formula weight | 2672.5 | |
All* | Total formula weight | 394227.7 |