Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

6C42

Estrogen Receptor Alpha Ligand Binding Domain in Complex with OP1156

Replaces:  5UF9
Summary for 6C42
Entry DOI10.2210/pdb6c42/pdb
DescriptorEstrogen receptor, (2R,3S,4R)-3-(4-hydroxyphenyl)-4-methyl-2-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-3,4-dihydro-2H-1-benzopyran-7-ol (3 entities in total)
Functional Keywordsestrogen receptor alpha, antiestrogen, selective estrogen receptor degrader, endocrine therapy, steroid receptor, nuclear hormone receptor, breast cancer, acquired antiestrogen resistance, transcription, trascription-transcription inhibitor complex, trascription/transcription inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight57601.51
Authors
Fanning, S.W.,Hodges-Gallager, L.,Myles, D.C.,Sun, R.,Fowler, C.E.,Green, B.D.,Harmon, C.L.,Greene, G.L.,Kushner, P.J. (deposition date: 2018-01-11, release date: 2018-02-14, Last modification date: 2023-10-04)
Primary citationFanning, S.W.,Hodges-Gallagher, L.,Myles, D.C.,Sun, R.,Fowler, C.E.,Plant, I.N.,Green, B.D.,Harmon, C.L.,Greene, G.L.,Kushner, P.J.
Specific stereochemistry of OP-1074 disrupts estrogen receptor alpha helix 12 and confers pure antiestrogenic activity.
Nat Commun, 9:2368-2368, 2018
Cited by
PubMed: 29915250
DOI: 10.1038/s41467-018-04413-3
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.997 Å)
Structure validation

217705

数据于2024-03-27公开中

PDB statisticsPDBj update infoContact PDBjnumon