6C42

Estrogen Receptor Alpha Ligand Binding Domain in Complex with OP1156

「5UF9」から置き換えられました

6C42 の概要

• エントリーDOI: 10.2210/pdb6c42/pdb
• 分子名称: Estrogen receptor, (2R,3S,4R)-3-(4-hydroxyphenyl)-4-methyl-2-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-3,4-dihydro-2H-1-benzopyran-7-ol (3 entities in total)
• 機能のキーワード: estrogen receptor alpha, antiestrogen, selective estrogen receptor degrader, endocrine therapy, steroid receptor, nuclear hormone receptor, breast cancer, acquired antiestrogen resistance, transcription, trascription-transcription inhibitor complex, trascription/transcription inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 57601.51

構造登録者

Fanning, S.W.,Hodges-Gallager, L.,Myles, D.C.,Sun, R.,Fowler, C.E.,Green, B.D.,Harmon, C.L.,Greene, G.L.,Kushner, P.J. (登録日: 2018-01-11, 公開日: 2018-02-14, 最終更新日: 2023-10-04)

• 主引用文献: Fanning, S.W.,Hodges-Gallagher, L.,Myles, D.C.,Sun, R.,Fowler, C.E.,Plant, I.N.,Green, B.D.,Harmon, C.L.,Greene, G.L.,Kushner, P.J.; Specific stereochemistry of OP-1074 disrupts estrogen receptor alpha helix 12 and confers pure antiestrogenic activity.; Nat Commun, 9:2368-2368, 2018; PubMed: 29915250; DOI: 10.1038/s41467-018-04413-3

実験手法

X-RAY DIFFRACTION (1.997 Å)