6C0U
Crystal structure of cAMP-dependent protein kinase Calpha subunit bound with N46
Summary for 6C0U
Entry DOI | 10.2210/pdb6c0u/pdb |
Related | 6C0T |
Descriptor | cAMP-dependent protein kinase catalytic subunit alpha, N-[(3R,4R)-4-{[4-(2-fluoro-3-methoxy-6-propoxybenzene-1-carbonyl)benzene-1-carbonyl]amino}pyrrolidin-3-yl]-1H-indazole-5-carboxamide, DIMETHYL SULFOXIDE, ... (5 entities in total) |
Functional Keywords | serine/threonine protein kinase (ec 2.7.11.11), transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 41979.80 |
Authors | Qin, L.,Sankaran, B.,Kim, C. (deposition date: 2018-01-02, release date: 2018-05-30, Last modification date: 2023-10-04) |
Primary citation | Qin, L.,Sankaran, B.,Aminzai, S.,Casteel, D.E.,Kim, C. Structural basis for selective inhibition of human PKG I alpha by the balanol-like compound N46. J. Biol. Chem., 293:10985-10992, 2018 Cited by PubMed: 29769318DOI: 10.1074/jbc.RA118.002427 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.65 Å) |
Structure validation
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