6C0T

Crystal structure of cGMP-dependent protein kinase Ialpha (PKG Ialpha) catalytic domain bound with N46

Summary for 6C0T

Entry DOI	10.2210/pdb6c0t/pdb
Related	6C0U
Descriptor	cGMP-dependent protein kinase 1, N-[(3R,4R)-4-{[4-(2-fluoro-3-methoxy-6-propoxybenzene-1-carbonyl)benzene-1-carbonyl]amino}pyrrolidin-3-yl]-1H-indazole-5-carboxamide, DIMETHYL SULFOXIDE, ... (5 entities in total)
Functional Keywords	serine/threonine protein kinases (ec 2.7.11.12), transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	40261.66
Authors	Qin, L.,Sankaran, B.,Kim, C. (deposition date: 2018-01-02, release date: 2018-05-30, Last modification date: 2023-10-04)
Primary citation	Qin, L.,Sankaran, B.,Aminzai, S.,Casteel, D.E.,Kim, C. Structural basis for selective inhibition of human PKG I alpha by the balanol-like compound N46. J. Biol. Chem., 293:10985-10992, 2018 Cited by PubMed: 29769318 DOI: 10.1074/jbc.RA118.002427 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.98 Å)

Structure validation