6C0T
Crystal structure of cGMP-dependent protein kinase Ialpha (PKG Ialpha) catalytic domain bound with N46
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | cGMP-dependent protein kinase 1 | polymer | 347 | 39473.8 | 1 | UniProt (Q13976) Pfam (PF00069) | Homo sapiens (Human) | cGK1,cGMP-dependent protein kinase I,cGKI |
| 2 | B (A) | N-[(3R,4R)-4-{[4-(2-fluoro-3-methoxy-6-propoxybenzene-1-carbonyl)benzene-1-carbonyl]amino}pyrrolidin-3-yl]-1H-indazole-5-carboxamide | non-polymer | 559.6 | 1 | Chemie (EE4) | |||
| 3 | C (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 4 | D (A) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 1 | Chemie (PGE) | |||
| 5 | E (A) | water | water | 18.0 | 98 | Chemie (HOH) |
Sequence modifications
A: 327 - 671 (UniProt: Q13976)
| PDB | External Database | Details |
|---|---|---|
| Gly 325 | - | expression tag |
| Ser 326 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 39473.8 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 787.9 | |
| All* | Total formula weight | 40261.7 |
