6BYO
Residue assignment correction to the voltage gated calcium Cav1.1 rabbit alpha 1 subunit PDB entries 3JBR & 5GJV
Summary for 6BYO
| Entry DOI | 10.2210/pdb6byo/pdb |
| Related | 3JBR 5GJV |
| EMDB information | 9513 |
| Descriptor | Voltage-dependent L-type calcium channel subunit alpha-1S (1 entity in total) |
| Functional Keywords | voltage-gated calcium channels, membrane protein |
| Biological source | Oryctolagus cuniculus (Rabbit) |
| Total number of polymer chains | 1 |
| Total formula weight | 155063.56 |
| Authors | Cardozo, T.J.,Martinez-Ortiz, W. (deposition date: 2017-12-21, release date: 2018-05-02, Last modification date: 2024-10-16) |
| Primary citation | Martinez-Ortiz, W.,Cardozo, T.J. An Improved Method for Modeling Voltage-Gated Ion Channels at Atomic Accuracy Applied to Human CavChannels. Cell Rep, 23:1399-1408, 2018 Cited by PubMed Abstract: Voltage-gated ion channels (VGICs) are associated with hundreds of human diseases. To date, 3D structural models of human VGICs have not been reported. We developed a 3D structural integrity metric to rank the accuracy of all VGIC structures deposited in the PDB. The metric revealed inaccuracies in structural models built from recent single-particle, non-crystalline cryo-electron microscopy maps and enabled the building of highly accurate homology models of human Ca channel α subunits at atomic resolution. Human Ca Mendelian mutations mostly located to segments involved in the mechanism of voltage sensing and gating within the 3D structure, with multiple mutations targeting equivalent 3D structural locations despite eliciting distinct clinical phenotypes. The models also revealed that the architecture of the ion selectivity filter is highly conserved from bacteria to humans and between sodium and calcium VGICs. PubMed: 29719253DOI: 10.1016/j.celrep.2018.04.024 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (3.6 Å) |
Structure validation
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