6BYN

Crystal structure of WDR5-Mb(S4) monobody complex

Summary for 6BYN

• Entry DOI: 10.2210/pdb6byn/pdb
• Descriptor: WD repeat-containing protein 5, WDR5-binding Monobody, Mb(S4) (3 entities in total)
• Functional Keywords: beta-propeller, fibronectin, mll1, inhibitor, transcription
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 44087.89

Authors

Gupta, A.,Koide, S. (deposition date: 2017-12-21, release date: 2018-07-04, Last modification date: 2023-10-04)

• Primary citation: Gupta, A.,Xu, J.,Lee, S.,Tsai, S.T.,Zhou, B.,Kurosawa, K.,Werner, M.S.,Koide, A.,Ruthenburg, A.J.,Dou, Y.,Koide, S.; Facile target validation in an animal model with intracellularly expressed monobodies.; Nat. Chem. Biol., 14:895-900, 2018; PubMed: 30013062; DOI: 10.1038/s41589-018-0099-z

Experimental method

X-RAY DIFFRACTION (2.69 Å)