6BY8

Menin in complex with MI-1482

Summary for 6BY8

Entry DOI	10.2210/pdb6by8/pdb
Descriptor	Menin, 4-methyl-1-{[(2R)-5-oxomorpholin-2-yl]methyl}-5-[(4-{[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino}piperidin-1-yl)methyl]-1H-indole-2-carbonitrile, DIMETHYL SULFOXIDE, ... (7 entities in total)
Functional Keywords	protein binding, inhibitor
Biological source	Homo sapiens (Human) More
Total number of polymer chains	1
Total formula weight	56153.08
Authors	Borkin, T.,Klossowski, S.,Pollock, J.,Linhares, B.,Cierpicki, T.,Grembecka, J. (deposition date: 2017-12-20, release date: 2018-11-28, Last modification date: 2023-10-04)
Primary citation	Borkin, D.,Klossowski, S.,Pollock, J.,Miao, H.,Linhares, B.M.,Kempinska, K.,Jin, Z.,Purohit, T.,Wen, B.,He, M.,Sun, D.,Cierpicki, T.,Grembecka, J. Complexity of Blocking Bivalent Protein-Protein Interactions: Development of a Highly Potent Inhibitor of the Menin-Mixed-Lineage Leukemia Interaction. J.Med.Chem., 61:4832-4850, 2018 Cited by PubMed: 29738674 DOI: 10.1021/acs.jmedchem.8b00071 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation