6BX8
Human Mesotrypsin (PRSS3) Complexed with Tissue Factor Pathway Inhibitor Variant (TFPI1-KD1-K15R-I17C-I34C)
Summary for 6BX8
Entry DOI | 10.2210/pdb6bx8/pdb |
Related | 6HAR |
Descriptor | Trypsin-3, Tissue factor pathway inhibitor, SULFATE ION, ... (4 entities in total) |
Functional Keywords | hydrolase, hydrolase inhibitor |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 8 |
Total formula weight | 136141.38 |
Authors | Coban, M.,Sankaran, B.,Cohen, I.,Hockla, A.,Papo, N.,Radisky, E.S. (deposition date: 2017-12-18, release date: 2019-02-06, Last modification date: 2023-10-04) |
Primary citation | Cohen, I.,Coban, M.,Shahar, A.,Sankaran, B.,Hockla, A.,Lacham, S.,Caulfield, T.R.,Radisky, E.S.,Papo, N. Disulfide engineering of human Kunitz-type serine protease inhibitors enhances proteolytic stability and target affinity toward mesotrypsin. J. Biol. Chem., 294:5105-5120, 2019 Cited by PubMed: 30700553DOI: 10.1074/jbc.RA118.007292 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.98 Å) |
Structure validation
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