6BWK

Crystal structure of the human MLKL pseudokinase domain T357E/S358E mutant

Summary for 6BWK

Entry DOI	10.2210/pdb6bwk/pdb
Descriptor	Mixed lineage kinase domain-like protein, GLYCEROL (3 entities in total)
Functional Keywords	pseudokinase, necroptosis, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	33175.17
Authors	Cowan, A.D.,Czabotar, P.E.,Murphy, J.M. (deposition date: 2017-12-15, release date: 2018-06-27, Last modification date: 2023-10-04)
Primary citation	Petrie, E.J.,Sandow, J.J.,Jacobsen, A.V.,Smith, B.J.,Griffin, M.D.W.,Lucet, I.S.,Dai, W.,Young, S.N.,Tanzer, M.C.,Wardak, A.,Liang, L.Y.,Cowan, A.D.,Hildebrand, J.M.,Kersten, W.J.A.,Lessene, G.,Silke, J.,Czabotar, P.E.,Webb, A.I.,Murphy, J.M. Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis. Nat Commun, 9:2422-2422, 2018 Cited by PubMed: 29930286 DOI: 10.1038/s41467-018-04714-7 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.79 Å)

Structure validation