6BW5

Human GPT (DPAGT1) in complex with tunicamycin

6BW5 の概要

• エントリーDOI: 10.2210/pdb6bw5/pdb
• 分子名称: UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, Tunicamycin, (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate (3 entities in total)
• 機能のキーワード: n-linked glycosylation, endoplasmic reticulum, tunicamycin, natural product, transferase, transferase-antibiotic complex, transferase/antibiotic
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 194907.04

構造登録者

Yoo, J.,Kuk, A.C.Y.,Mashalidis, E.H.,Lee, S.-Y. (登録日: 2017-12-14, 公開日: 2018-02-21, 最終更新日: 2023-10-04)

• 主引用文献: Yoo, J.,Mashalidis, E.H.,Kuk, A.C.Y.,Yamamoto, K.,Kaeser, B.,Ichikawa, S.,Lee, S.Y.; GlcNAc-1-P-transferase-tunicamycin complex structure reveals basis for inhibition of N-glycosylation.; Nat. Struct. Mol. Biol., 25:217-224, 2018; PubMed: 29459785; DOI: 10.1038/s41594-018-0031-y

実験手法

X-RAY DIFFRACTION (3.1 Å)