6BRU

Crystal Structure of the Human vaccinia-related kinase bound to a (S)-2-phenylaminopteridinone inhibitor

Summary for 6BRU

• Entry DOI: 10.2210/pdb6bru/pdb
• Descriptor: Serine/threonine-protein kinase VRK1, SULFATE ION, (7S)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7,8-trimethyl-7,8-dihydropteridin-6(5H)-one, ... (5 entities in total)
• Functional Keywords: transferase, protein kinase domain, structural genomics, structural genomics consortium, sgc, transferase-transferase inhibitor complex, transferase-transferase inhbitor complex, transferase/transferase inhbitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 166149.75

Authors

Counago, R.M.,dos Reis, C.V.,de Souza, G.P.,Aquino, B.,Azevedo, A.,Guimaraes, C.,Mascarello, A.,Gama, F.,Ferreira, M.,Massirer, K.B.,Arruda, P.,Edwards, A.M.,Elkins, J.M.,Structural Genomics Consortium (SGC) (deposition date: 2017-12-01, release date: 2017-12-13, Last modification date: 2023-10-04)

• Primary citation: Counago, R.M.,dos Reis, C.V.,de Souza, G.P.,Aquino, B.,Azevedo, H.,Guimaraes, C.,Mascarello, A.,Gama, F.,Ferreira, M.,Massirer, K.B.,Arruda, P.,Edwards, A.M.,Elkins, J.M.,Structural Genomics Consortium (SGC); Crystal Structure of the Human vaccinia-related kinase bound to a (S)-2-phenylaminopteridinone inhibitor; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.8 Å)