6BQ8

Joint X-ray/neutron structure of PKG II CNB-B domain in complex with 8-pCPT-cGMP

6BQ8 の概要

• エントリーDOI: 10.2210/pdb6bq8/pdb
• 分子名称: cGMP-dependent protein kinase 2, 2-(~2~H_2_)amino-8-[(4-chlorophenyl)sulfanyl]-9-[(2S,4aR,6R,7R,7aS)-2-hydroxy-7-(~2~H)hydroxy-2-oxotetrahydro-2H,4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl](~2~H)-1,9-dihydro-6H-purin-6-one, STRONTIUM ION, ... (5 entities in total)
• 機能のキーワード: protein kinase g, regulatory domain, neutron crystallography, activator, hydrogen bonding, protonation state, signaling protein, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 18087.98

構造登録者

Kim, C.,Kovalevsky, A.,Gerlits, O. (登録日: 2017-11-27, 公開日: 2018-03-21, 最終更新日: 2024-04-03)

• 主引用文献: Gerlits, O.,Campbell, J.C.,Blakeley, M.P.,Kim, C.,Kovalevsky, A.; Neutron Crystallography Detects Differences in Protein Dynamics: Structure of the PKG II Cyclic Nucleotide Binding Domain in Complex with an Activator.; Biochemistry, 57:1833-1837, 2018; PubMed: 29517905; DOI: 10.1021/acs.biochem.8b00010

実験手法

NEUTRON DIFFRACTION (2.2 Å)
X-RAY DIFFRACTION (2 Å)