6BOJ

Crystal Structure of the PDE4D Catalytic Domain and UCR2 Regulatory Helix with BPN5004

Summary for 6BOJ

• Entry DOI: 10.2210/pdb6boj/pdb
• Descriptor: cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ... (7 entities in total)
• Functional Keywords: pde4d, camp-specific 3'5'-cyclic phosphodiesterase 4d, ucr2, camp, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 172703.46

Authors

Fox III, D.,Fairman, J.W.,Gurney, M.E. (deposition date: 2017-11-20, release date: 2018-08-22, Last modification date: 2024-03-13)

• Primary citation: Zhang, C.,Xu, Y.,Chowdhary, A.,Fox 3rd., D.,Gurney, M.E.,Zhang, H.T.,Auerbach, B.D.,Salvi, R.J.,Yang, M.,Li, G.,O'Donnell, J.M.; Memory enhancing effects of BPN14770, an allosteric inhibitor of phosphodiesterase-4D, in wild-type and humanized mice.; Neuropsychopharmacology, 43:2299-2309, 2018; PubMed: 30131563; DOI: 10.1038/s41386-018-0178-6

Experimental method

X-RAY DIFFRACTION (1.7 Å)