6BOJ
Crystal Structure of the PDE4D Catalytic Domain and UCR2 Regulatory Helix with BPN5004
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | polymer | 370 | 42593.1 | 4 | UniProt (Q08499) UniProt (Q07343) Pfam (PF00233) In PDB | Homo sapiens (Human) | DPDE3,PDE43 |
2 | A, B, C, D | ZINC ION | non-polymer | 65.4 | 6 | Chemie (ZN) | |||
3 | A, B, C, D | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
4 | A, B, C, D | 2-(4-{[2-(3-chlorophenyl)-6-ethylpyrimidin-4-yl]methyl}phenyl)acetamide | non-polymer | 365.9 | 4 | Chemie (E31) | |||
5 | A, B, C, D | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
6 | B, C | (4S)-2-METHYL-2,4-PENTANEDIOL | non-polymer | 118.2 | 2 | Chemie (MPD) | |||
7 | water | water | 18.0 | 1132 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 244 - 578 (UniProt: Q08499)
A, B, C, D: 579 - 592 (UniProt: Q07343)
A, B, C, D: 593 - 606 (UniProt: Q08499)
PDB | External Database | Details |
---|---|---|
Met 243 | - | initiating methionine |
PDB | External Database | Details |
---|---|---|
Ala 579 | Ser 659 | engineered mutation |
Ala 581 | Ser 661 | engineered mutation |
Ser 591 | Cys 671 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Glu 607 | - | expression tag |
Asn 608 | - | expression tag |
Leu 609 | - | expression tag |
Tyr 610 | - | expression tag |
Phe 611 | - | expression tag |
Gln 612 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 170372.2 | |
Non-Polymers* | Number of molecules | 20 |
Total formula weight | 2331.3 | |
All* | Total formula weight | 172703.5 |