6BNC

Crystal structure of the intrinsic colistin resistance enzyme ICR(Mc) from Moraxella catarrhalis, catalytic domain, Thr315Ala mutant di-zinc and PEG complex

6BNC の概要

• エントリーDOI: 10.2210/pdb6bnc/pdb
• 関連するPDBエントリー: 6BND 6BNE 6BNF
• 分子名称: Phosphoethanolamine transferase, ZINC ION, POLYETHYLENE GLYCOL (N=34), ... (5 entities in total)
• 機能のキーワード: antibiotic resistance, colistin, polymycin, phosphoethanolamine transferase, sulfatase fold, alpha/beta protein, structural genomics, center for structural genomics of infectious diseases, csgid, transferase
• 由来する生物種: Moraxella sp. HMSC061H09
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 89948.25

構造登録者

Stogios, P.J.,Evdokimova, E.,Wawrzak, Z.,Savchenko, A.,Anderson, W.F.,Satchell, K.J.,Joachimiak, A.,Center for Structural Genomics of Infectious Diseases (CSGID) (登録日: 2017-11-16, 公開日: 2018-01-31, 最終更新日: 2019-12-11)

• 主引用文献: Stogios, P.J.,Cox, G.,Zubyk, H.L.,Evdokimova, E.,Wawrzak, Z.,Wright, G.D.,Savchenko, A.; Substrate Recognition by a Colistin Resistance Enzyme from Moraxella catarrhalis.; ACS Chem. Biol., 13:1322-1332, 2018; PubMed: 29631403; DOI: 10.1021/acschembio.8b00116

実験手法

X-RAY DIFFRACTION (1.5 Å)