6BNC

Crystal structure of the intrinsic colistin resistance enzyme ICR(Mc) from Moraxella catarrhalis, catalytic domain, Thr315Ala mutant di-zinc and PEG complex

Summary for 6BNC

• Entry DOI: 10.2210/pdb6bnc/pdb
• Related: 6BND 6BNE 6BNF
• Descriptor: Phosphoethanolamine transferase, ZINC ION, POLYETHYLENE GLYCOL (N=34), ... (5 entities in total)
• Functional Keywords: antibiotic resistance, colistin, polymycin, phosphoethanolamine transferase, sulfatase fold, alpha/beta protein, structural genomics, center for structural genomics of infectious diseases, csgid, transferase
• Biological source: Moraxella sp. HMSC061H09
• Total number of polymer chains: 2
• Total formula weight: 89948.25

Authors

Stogios, P.J.,Evdokimova, E.,Wawrzak, Z.,Savchenko, A.,Anderson, W.F.,Satchell, K.J.,Joachimiak, A.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2017-11-16, release date: 2018-01-31, Last modification date: 2019-12-11)

• Primary citation: Stogios, P.J.,Cox, G.,Zubyk, H.L.,Evdokimova, E.,Wawrzak, Z.,Wright, G.D.,Savchenko, A.; Substrate Recognition by a Colistin Resistance Enzyme from Moraxella catarrhalis.; ACS Chem. Biol., 13:1322-1332, 2018; PubMed: 29631403; DOI: 10.1021/acschembio.8b00116

Experimental method

X-RAY DIFFRACTION (1.5 Å)