6BM7

Crystal structure of Trypanosoma brucei AdoMetDC/prozyme heterodimer in complex with pyrimidineamine inhibitor UTSAM568

Summary for 6BM7

• Entry DOI: 10.2210/pdb6bm7/pdb
• Descriptor: S-adenosylmethionine decarboxylase beta chain, S-adenosylmethionine decarboxylase alpha chain, Inactive S-adenosylmethionine decarboxylase prozyme, ... (9 entities in total)
• Functional Keywords: adometdc, prozyme, decarboxylase, trypanosoma, inhibitor, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• Biological source: Trypanosoma brucei brucei (strain 927/4 GUTat10.1); More
• Total number of polymer chains: 6
• Total formula weight: 158233.26

Authors

Volkov, O.A.,Chen, Z.,Phillips, M.A. (deposition date: 2017-11-13, release date: 2018-01-03, Last modification date: 2023-11-15)

• Primary citation: Volkov, O.A.,Brockway, A.J.,Wring, S.A.,Peel, M.,Chen, Z.,Phillips, M.A.,De Brabander, J.K.; Species-Selective Pyrimidineamine Inhibitors of Trypanosoma brucei S-Adenosylmethionine Decarboxylase.; J. Med. Chem., 61:1182-1203, 2018; PubMed: 29271204; DOI: 10.1021/acs.jmedchem.7b01654

Experimental method

X-RAY DIFFRACTION (2.98 Å)