6BM7

Crystal structure of Trypanosoma brucei AdoMetDC/prozyme heterodimer in complex with pyrimidineamine inhibitor UTSAM568

6BM7 の概要

• エントリーDOI: 10.2210/pdb6bm7/pdb
• 分子名称: S-adenosylmethionine decarboxylase beta chain, S-adenosylmethionine decarboxylase alpha chain, Inactive S-adenosylmethionine decarboxylase prozyme, ... (9 entities in total)
• 機能のキーワード: adometdc, prozyme, decarboxylase, trypanosoma, inhibitor, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• 由来する生物種: Trypanosoma brucei brucei (strain 927/4 GUTat10.1); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 158233.26

構造登録者

Volkov, O.A.,Chen, Z.,Phillips, M.A. (登録日: 2017-11-13, 公開日: 2018-01-03, 最終更新日: 2023-11-15)

• 主引用文献: Volkov, O.A.,Brockway, A.J.,Wring, S.A.,Peel, M.,Chen, Z.,Phillips, M.A.,De Brabander, J.K.; Species-Selective Pyrimidineamine Inhibitors of Trypanosoma brucei S-Adenosylmethionine Decarboxylase.; J. Med. Chem., 61:1182-1203, 2018; PubMed: 29271204; DOI: 10.1021/acs.jmedchem.7b01654

実験手法

X-RAY DIFFRACTION (2.98 Å)