6BLX

Crystal structure of IAg7 in complex with insulin mimotope p8G9E

Summary for 6BLX

• Entry DOI: 10.2210/pdb6blx/pdb
• Related: 6BLQ 6BLR
• Descriptor: H-2 class II histocompatibility antigen, A-D alpha chain, H2-Ab1 protein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: type 1 diabetes, t cell autoimmunity, mhc classii, immune system
• Biological source: Mus musculus (Mouse); More
• Total number of polymer chains: 2
• Total formula weight: 47137.53

Authors

Wang, Y.,Dai, S. (deposition date: 2017-11-11, release date: 2017-12-20, Last modification date: 2020-07-29)

• Primary citation: Wang, Y.,Sosinowski, T.,Novikov, A.,Crawford, F.,Neau, D.B.,Yang, J.,Kwok, W.W.,Marrack, P.,Kappler, J.W.,Dai, S.; C-terminal modification of the insulin B:11-23 peptide creates superagonists in mouse and human type 1 diabetes.; Proc. Natl. Acad. Sci. U.S.A., 115:162-167, 2018; PubMed: 29255035; DOI: 10.1073/pnas.1716527115

Experimental method

X-RAY DIFFRACTION (2.323 Å)