6BLW

Zinc finger Domain of WT1(+KTS form) with M342R Mutation and 17+1mer Oligonucleotide with Triplet GGT

6BLW の概要

• エントリーDOI: 10.2210/pdb6blw/pdb
• 分子名称: Wilms tumor protein, DNA (5'-D(P*GP*CP*GP*AP*AP*AP*TP*GP*GP*GP*AP*GP*GP*GP*TP*T)-3'), DNA (5'-D(*TP*AP*AP*CP*CP*CP*TP*CP*CP*CP*AP*TP*TP*TP*CP*GP*C)-3'), ... (7 entities in total)
• 機能のキーワード: protein-dna complex wilms tumor suppressor protein zinc-fingers, dna binding protein-dna complex, dna binding protein/dna
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Nucleus . Isoform 1: Nucleus speckle . Isoform 4: Nucleus, nucleoplasm : P19544
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 26862.75

構造登録者

Horton, J.R.,Cheng, X. (登録日: 2017-11-11, 公開日: 2018-01-03, 最終更新日: 2018-05-16)

• 主引用文献: Wang, D.,Horton, J.R.,Zheng, Y.,Blumenthal, R.M.,Zhang, X.,Cheng, X.; Role for first zinc finger of WT1 in DNA sequence specificity: Denys-Drash syndrome-associated WT1 mutant in ZF1 enhances affinity for a subset of WT1 binding sites.; Nucleic Acids Res., 46:3864-3877, 2018; PubMed: 29294058; DOI: 10.1093/nar/gkx1274

実験手法

X-RAY DIFFRACTION (1.835 Å)