Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

6BGU

LINKED KDM5A JMJ DOMAIN BOUND TO THE INHIBITOR 2-((2-chlorophenyl)(propoxy)methyl)-1H-pyrrolo[3,2-b]pyridine (Compound N9)

Summary for 6BGU
Entry DOI10.2210/pdb6bgu/pdb
DescriptorLysine-specific demethylase 5A, linked KDM5A JMJ domain, 2-[(R)-(2-chlorophenyl)(propoxy)methyl]-1H-pyrrolo[3,2-b]pyridine-7-carboxylic acid, MANGANESE (II) ION, ... (8 entities in total)
Functional Keywordsdemethylase inhibition, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains1
Total formula weight38951.22
Authors
Horton, J.R.,Cheng, X. (deposition date: 2017-10-29, release date: 2018-03-28, Last modification date: 2023-10-04)
Primary citationHorton, J.R.,Liu, X.,Wu, L.,Zhang, K.,Shanks, J.,Zhang, X.,Rai, G.,Mott, B.T.,Jansen, D.J.,Kales, S.C.,Henderson, M.J.,Pohida, K.,Fang, Y.,Hu, X.,Jadhav, A.,Maloney, D.J.,Hall, M.D.,Simeonov, A.,Fu, H.,Vertino, P.M.,Yan, Q.,Cheng, X.
Insights into the Action of Inhibitor Enantiomers against Histone Lysine Demethylase 5A.
J. Med. Chem., 61:3193-3208, 2018
Cited by
PubMed: 29537847
DOI: 10.1021/acs.jmedchem.8b00261
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.684 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon