6BGU
LINKED KDM5A JMJ DOMAIN BOUND TO THE INHIBITOR 2-((2-chlorophenyl)(propoxy)methyl)-1H-pyrrolo[3,2-b]pyridine (Compound N9)
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 16 |
Details | binding site for residue DKP A 601 |
Chain | Residue |
A | ARG73 |
A | LYS501 |
A | TRP503 |
A | GLN535 |
A | HIS571 |
A | MN602 |
A | HOH816 |
A | HOH847 |
A | GLN75 |
A | TYR409 |
A | ALA411 |
A | TYR472 |
A | SER479 |
A | PHE480 |
A | HIS483 |
A | ASN493 |
site_id | AC2 |
Number of Residues | 6 |
Details | binding site for residue MN A 602 |
Chain | Residue |
A | HIS483 |
A | GLU485 |
A | HIS571 |
A | DKP601 |
A | HOH734 |
A | HOH816 |
site_id | AC3 |
Number of Residues | 2 |
Details | binding site for residue DMS A 603 |
Chain | Residue |
A | ASP531 |
A | TYR570 |
site_id | AC4 |
Number of Residues | 7 |
Details | binding site for residue GOL A 604 |
Chain | Residue |
A | GLY353 |
A | ALA357 |
A | VAL358 |
A | MET384 |
A | SER508 |
A | PRO567 |
A | ARG568 |
site_id | AC5 |
Number of Residues | 9 |
Details | binding site for residue GOL A 605 |
Chain | Residue |
A | TRP395 |
A | PHE480 |
A | CYS481 |
A | TRP482 |
A | THR538 |
A | ILE539 |
A | MET540 |
A | SER572 |
A | GLY573 |
site_id | AC6 |
Number of Residues | 3 |
Details | binding site for residue EDO A 606 |
Chain | Residue |
A | ASN379 |
A | GLU515 |
A | ARG568 |
site_id | AC7 |
Number of Residues | 5 |
Details | binding site for residue EDO A 607 |
Chain | Residue |
A | MET380 |
A | PRO381 |
A | ASP486 |
A | HIS487 |
A | HOH707 |
site_id | AC8 |
Number of Residues | 4 |
Details | binding site for residue EDO A 608 |
Chain | Residue |
A | GLU64 |
A | VAL65 |
A | LYS66 |
A | ARG429 |
site_id | AC9 |
Number of Residues | 2 |
Details | binding site for residue EDO A 609 |
Chain | Residue |
A | PRO53 |
A | HOH771 |
site_id | AD1 |
Number of Residues | 7 |
Details | binding site for residue SO4 A 610 |
Chain | Residue |
A | ARG76 |
A | LEU77 |
A | GLU79 |
A | SER479 |
A | ILE539 |
A | HOH702 |
A | HOH744 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 50 |
Details | ZN_FING: PHD-type 1 => ECO:0000255|PROSITE-ProRule:PRU00146 |
Chain | Residue | Details |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:26645689, ECO:0000269|PubMed:27427228 |
Chain | Residue | Details |
A | TYR409 | |
A | SER491 | |
A | ASN493 | |
A | LYS501 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000305|PubMed:26645689, ECO:0000305|PubMed:27214401, ECO:0000305|PubMed:27427228, ECO:0000305|PubMed:27499454 |
Chain | Residue | Details |
A | HIS483 | |
A | HIS571 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000305|PubMed:26645689, ECO:0000305|PubMed:27214401, ECO:0000305|PubMed:27427228, ECO:0000305|PubMed:27499454 |
Chain | Residue | Details |
A | GLU485 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER464 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
Chain | Residue | Details |
A | LEU451 |