6BFQ
The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies
Summary for 6BFQ
Entry DOI | 10.2210/pdb6bfq/pdb |
Descriptor | Fab Heavy chain, Fab Light Chain, Granulocyte-macrophage colony-stimulating factor, ... (4 entities in total) |
Functional Keywords | cytokine-fab complex, pulmonary alveolar proteinosis, receptor assembly, autoantibodies, immune system |
Biological source | Homo sapiens More |
Total number of polymer chains | 12 |
Total formula weight | 247457.83 |
Authors | Dhagat, U.,Hercus, T.R.,Broughton, S.E.,Nero, T.L.,Lopez, A.F.,Parker, M.W. (deposition date: 2017-10-26, release date: 2018-09-12, Last modification date: 2023-10-04) |
Primary citation | Dhagat, U.,Hercus, T.R.,Broughton, S.E.,Nero, T.L.,Cheung Tung Shing, K.S.,Barry, E.F.,Thomson, C.A.,Bryson, S.,Pai, E.F.,McClure, B.J.,Schrader, J.W.,Lopez, A.F.,Parker, M.W. The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities. MAbs, 10:1018-1029, 2018 Cited by PubMed: 29969365DOI: 10.1080/19420862.2018.1494107 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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