6BFQ

The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies

Summary for 6BFQ

• Entry DOI: 10.2210/pdb6bfq/pdb
• Descriptor: Fab Heavy chain, Fab Light Chain, Granulocyte-macrophage colony-stimulating factor, ... (4 entities in total)
• Functional Keywords: cytokine-fab complex, pulmonary alveolar proteinosis, receptor assembly, autoantibodies, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 12
• Total formula weight: 247457.83

Authors

Dhagat, U.,Hercus, T.R.,Broughton, S.E.,Nero, T.L.,Lopez, A.F.,Parker, M.W. (deposition date: 2017-10-26, release date: 2018-09-12, Last modification date: 2023-10-04)

• Primary citation: Dhagat, U.,Hercus, T.R.,Broughton, S.E.,Nero, T.L.,Cheung Tung Shing, K.S.,Barry, E.F.,Thomson, C.A.,Bryson, S.,Pai, E.F.,McClure, B.J.,Schrader, J.W.,Lopez, A.F.,Parker, M.W.; The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities.; MAbs, 10:1018-1029, 2018; PubMed: 29969365; DOI: 10.1080/19420862.2018.1494107

Experimental method

X-RAY DIFFRACTION (2.6 Å)