6BC7
Cryo X-ray structure of sisomicin bound AAC-VIa
Summary for 6BC7
| Entry DOI | 10.2210/pdb6bc7/pdb |
| Descriptor | AAC 3-VI protein, (1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranoside, ACETATE ION, ... (4 entities in total) |
| Functional Keywords | acetyltransferase, sisomicin, transferase-antibiotic complex, transferase/antibiotic |
| Biological source | Enterobacter cloacae |
| Total number of polymer chains | 1 |
| Total formula weight | 32851.03 |
| Authors | Cuneo, M.J.,Kumar, P. (deposition date: 2017-10-20, release date: 2018-02-28, Last modification date: 2023-10-04) |
| Primary citation | Kumar, P.,Serpersu, E.H.,Cuneo, M.J. A low-barrier hydrogen bond mediates antibiotic resistance in a noncanonical catalytic triad. Sci Adv, 4:eaas8667-eaas8667, 2018 Cited by PubMed: 29632894DOI: 10.1126/sciadv.aas8667 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
Download full validation report
