6BC1

A Complex between PH Domain of p190RhoGEF and Activated Rac1 Bound to a GTP Analog

Summary for 6BC1

Entry DOI	10.2210/pdb6bc1/pdb
Descriptor	Ras-related C3 botulinum toxin substrate 1, Rho guanine nucleotide exchange factor 28, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, ... (5 entities in total)
Functional Keywords	rho gtpase guanine nucleotide exchange factors rhogef pleckstrin homology ph domain, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	77204.57
Authors	Chen, Z.,Sternweis, P.C. (deposition date: 2017-10-20, release date: 2017-12-13, Last modification date: 2024-03-13)
Primary citation	Dada, O.,Gutowski, S.,Brautigam, C.A.,Chen, Z.,Sternweis, P.C. Direct regulation of p190RhoGEF by activated Rho and Rac GTPases. J. Struct. Biol., 202:13-24, 2018 Cited by PubMed: 29196061 DOI: 10.1016/j.jsb.2017.11.014 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation