6BA2
Crystal structure of MYST acetyltransferase domain in complex with inhibitor
Summary for 6BA2
Entry DOI | 10.2210/pdb6ba2/pdb |
Descriptor | Histone acetyltransferase KAT8, CHLORIDE ION, ZINC ION, ... (7 entities in total) |
Functional Keywords | acetyltransferase, inhibitor, complex, myst, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 35402.34 |
Authors | Hermans, S.J.,Chung, M.C.,Peat, T.S.,Baell, J.B.,Thomas, T.,Parker, M.W. (deposition date: 2017-10-11, release date: 2018-08-01, Last modification date: 2020-01-08) |
Primary citation | Baell, J.B.,Leaver, D.J.,Hermans, S.J.,Kelly, G.L.,Brennan, M.S.,Downer, N.L.,Nguyen, N.,Wichmann, J.,McRae, H.M.,Yang, Y.,Cleary, B.,Lagiakos, H.R.,Mieruszynski, S.,Pacini, G.,Vanyai, H.K.,Bergamasco, M.I.,May, R.E.,Davey, B.K.,Morgan, K.J.,Sealey, A.J.,Wang, B.,Zamudio, N.,Wilcox, S.,Garnham, A.L.,Sheikh, B.N.,Aubrey, B.J.,Doggett, K.,Chung, M.C.,de Silva, M.,Bentley, J.,Pilling, P.,Hattarki, M.,Dolezal, O.,Dennis, M.L.,Falk, H.,Ren, B.,Charman, S.A.,White, K.L.,Rautela, J.,Newbold, A.,Hawkins, E.D.,Johnstone, R.W.,Huntington, N.D.,Peat, T.S.,Heath, J.K.,Strasser, A.,Parker, M.W.,Smyth, G.K.,Street, I.P.,Monahan, B.J.,Voss, A.K.,Thomas, T. Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth. Nature, 560:253-257, 2018 Cited by PubMed: 30069049DOI: 10.1038/s41586-018-0387-5 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85003821102 Å) |
Structure validation
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