6BA2
Crystal structure of MYST acetyltransferase domain in complex with inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Histone acetyltransferase KAT8 | polymer | 295 | 34433.6 | 1 | UniProt (Q9H7Z6) Pfam (PF17772) Pfam (PF01853) In PDB | Homo sapiens (Human) | Lysine acetyltransferase 8,MOZ,YBF2/SAS3,SAS2 and TIP60 protein 1,hMOF |
2 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
3 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
4 | A | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
5 | A | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
6 | A | 4-fluoro-5-methyl-N'-(phenylsulfonyl)[1,1'-biphenyl]-3-carbohydrazide | non-polymer | 384.4 | 1 | Chemie (7KM) | |||
7 | water | water | 18.0 | 143 | Chemie (HOH) |
Sequence modifications
A: 504 - 779 (UniProt: Q9H7Z6)
PDB | External Database | Details |
---|---|---|
Met 485 | - | initiating methionine |
Gly 486 | - | expression tag |
Ser 487 | - | expression tag |
Ser 488 | - | expression tag |
His 489 | - | expression tag |
His 490 | - | expression tag |
His 491 | - | expression tag |
His 492 | - | expression tag |
His 493 | - | expression tag |
His 494 | - | expression tag |
Ser 495 | - | expression tag |
Ser 496 | - | expression tag |
Gly 497 | - | expression tag |
Leu 498 | - | expression tag |
Val 499 | - | expression tag |
Pro 500 | - | expression tag |
Arg 501 | - | expression tag |
Gly 502 | - | expression tag |
Ser 503 | - | expression tag |
His 579 | Tyr 249 | conflict |
Ser 645 | Ala 315 | conflict |
Met 648 | Leu 318 | conflict |
Ile 649 | Thr 319 | conflict |
Arg 660 | Lys 330 | conflict |
Ser 697 | Trp 367 | conflict |
Asn 702 | Ile 372 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 34433.6 | |
Non-Polymers* | Number of molecules | 9 |
Total formula weight | 968.7 | |
All* | Total formula weight | 35402.3 |